Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Ip, CKM; Ng, PKS; Jeong, KJ; Shao, SH; Ju, ZL; Leonard, PG; Hua, X; Vellano, CP; Woessner, R; Sahni, N; Scott, KL; Mills, GB

Ip, CKM (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, 1515 Holcombe Blvd, Houston, TX 77030 USA.

NATURE COMMUNICATIONS, 2018; 9 ():

Abstract

Activation of platelet-derived growth factor receptor alpha (PDGFRA) by genomic aberrations contributes to tumor progression in several tumor types. I......

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