Caspase-11 promotes allergic airway inflammation

Zaslona, Z; Flis, E; Wilk, MM; Carroll, RG; Palsson-McDermott, EM; Hughes, MM; Diskin, C; Banahan, K; Ryan, DG; Hooftman, A; Misiak, A; Kearney, J; Lochnit, G; Bertrams, W; Greulich, T; Schmeck, B; McElvaney, OJ; Mills, KHG; Lavelle, EC; Wygreck, M; Creagh, EM; O'Neill, LAJ

Zaslona, Z (corresponding author), Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst TBSI, Dublin, Ireland.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E-2 (PGE(2)) inhibit......

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