Sorafenib Dose Recommendation in Acute Myeloid Leukemia Based on Exposure-FLT3 Relationship

Liu, T; Ivaturi, V; Sabato, P; Gobburu, JVS; Greer, JM; Wright, JJ; Smith, BD; Pratz, KW; Rudek, MA

Ivaturi, V (reprint author), Univ Maryland Baltimore, Ctr Translat Med, Baltimore, MD 21201 USA.; Rudek, MA (reprint author), Johns Hopkins Univ, Dept Med, Div Clin Pharmacol, Baltimore, MD USA.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2018; 11 (4): 435

Abstract

Sorafenib administered at the approved dose continuously is not tolerated long-term in patients with acute myeloid leukemia (AML). The purpose of this......

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