A biophysical framework for double- drugging kinases

Kim, C; Ludewig, H; Hadzipasic, A; Kutter, S; Nguyen, V; Kern, D

Kern, D (通讯作者),Brandeis Univ, Dept Biochem, Waltham, MA 02454 USA.;Kern, D (通讯作者),Brandeis Univ, HHMI, Waltham, MA 02454 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023; 120 (34):

Abstract

Selective orthosteric inhibition of kinases has been challenging due to the conserved active site architecture of kinases and emergence of resistance ......

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