Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to beta-catenin that requires AGR2 dimerization and adhesion domains

Merugu, SB; Zhou, BJ; Mangukiya, HB; Negi, H; Ghulam, R; Roy, D; Qudsia, S; Wang, ZL; Mashausi, DS; Yunus, FUN; Liu, GS; Li, DW

Merugu, SB (corresponding author), Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021; 573 (): 86

Abstract

Anterior gradient 2 (AGR2) is often overexpressed in several types of cancer. AGR2 is cytoplasmic or secreted as an extracellular signal. Intracellula......

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