Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

Zhang, MJY; Hou, KC; Dey, KK; Sakaue, S; Jagadeesh, KA; Weinand, K; Taychameekiatchai, A; Rao, P; Pisco, AO; Zou, J; Wang, B; Gandal, M; Raychaudhuri, S; Pasaniuc, B; Price, AL

Zhang, MJY; Price, AL (通讯作者),Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Zhang, MJY; Price, AL (通讯作者),Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Hou, KC; Pasaniuc, B (通讯作者),Univ Calif Los Angeles, Bioinformat Interdept Program, Los Angeles, CA 90095 USA.;Hou, KC; Pasaniuc, B (通讯作者),Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA.;Hou, KC; Pasaniuc, B (通讯作者),Univ Calif Los Angeles, David G

NATURE GENETICS, 2022; 54 (10): 1572

Abstract

scDRS associates individual cells in scRNA-seq with disease by scoring single-cell transcriptomes using GWAS gene signatures. Applied to 74 GWAS and 1......

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