Hyposialylated IgG activates endothelial IgG receptor Fc gamma RIIB to promote obesity-induced insulin resistance

Tanigaki, K; Sacharidou, A; Peng, J; Chambliss, KL; Yuhanna, IS; Ghosh, D; Ahmed, M; Szalai, AJ; Vongpatanasin, W; Mattrey, RF; Chen, QS; Azadi, P; Lingvay, I; Botto, M; Holland, WL; Kohler, JJ; Sirsi, SR; Hoyt, K; Shaul, PW; Mineo, C

Shaul, PW; Mineo, C (reprint author), Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2018; 128 (1): 309

Abstract

Type 2 diabetes mellitus (T2DM) is a common complication of obesity. Here, we have shown that activation of the IgG receptor Fc gamma RIIB in endothel......

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