Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs

Kurtz, S; Lucas-Hahn, A; Schlegelberger, B; Gohring, G; Niemann, H; Mettenleiter, TC; Petersen, B

Petersen, B (corresponding author), Friedrich Loeffler Inst, Inst Farm Anim Genet, D-31535 Neustadt, Germany.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021; 118 (2):

Abstract

The sex-determining region on the Y chromosome (SRY) is thought to be the central genetic element of male sex development in mammals. Pathogenic modif......

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