S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein

Fujikawa, K; Nakahara, K; Takasugi, N; Nishiya, T; Ito, A; Uchida, K; Uehara, T

Uehara, T (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med Pharmacol, 1-1-1 Tsushima Naka, Okayama 7008530, Japan.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020; 524 (4): 910

Abstract

S-Nitrosylation of protein cysteine thiol is a post-translational modification mediated by nitric oxide (NO). The overproduction of NO causes nitrosat......

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