PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1 beta Secretion

Le, S; Zhang, H; Huang, XF; Chen, S; Wu, J; Chen, SS; Ding, XC; Zhao, J; Xu, H; Cui, JK; Zou, YQ; Yu, JZ; Jiang, L; Wu, J; Ye, P; Xia, JH

Wu, J; Xia, JH (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiovasc Surg, Jiefang Rd 1277, Wuhan 430022, Hubei, Peoples R China.; Ye, P (corresponding author), Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Dept Cardiol, Tongji Med Coll, Shengli Rd 26, Wuhan 430014, Peoples R China.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2020; 25 (4): 364

Abstract

Background: The development of thoracic aortic aneurysm and dissection (TAAD) is mediated by inflammasome activation, which exacerbates the secretion ......

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