Gasdermin D pore-forming activity is redox-sensitive

Devant, P; Borsic, E; Ngwa, EM; Xiao, HP; Chouchani, ET; Thiagarajah, JR; Hafner-Bratkovic, I; Evavold, CL; Kagan, JC

Thiagarajah, JR; Kagan, JC (通讯作者)，Boston Childrens Hosp, Div Gastroenterol, 300 Longwood Ave, Boston, MA 02115 USA.;Thiagarajah, JR; Kagan, JC (通讯作者)，Harvard Med Sch, 300 Longwood Ave, Boston, MA 02115 USA.;Hafner-Bratkovic, I (通讯作者)，Natl Inst Chem, Dept Synthet Biol & Immunol, Hajdrihova 19, Ljubljana 1000, Slovenia.;Hafner-Bratkovic, I (通讯作者)，EN FIST Ctr Excellence, Trg Osvobodilne Fronte 13, Ljubljana 1000, Slovenia.;Evavold, CL (通讯作者)，MIT, Ragon Inst MGH, 400 Technol Sq, Cambridge, MA 02139 USA.

CELL REPORTS, 2023; 42 (1):

Abstract

Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mecha......

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