Design, synthesis, and biological evaluation of novel molecules as potent inhibitors of PLK1

Lu, J; Lei, H; Bai, XF; Wang, WY; Liu, CJ; Yang, YF; Zou, FX; Wang, L; Wang, YJ; Du, GY; Wang, X; Sun, CC; Yu, LS; Ma, MX; Ye, L; Wang, HB; Tian, JW; Zhang, JZ

Tian, JW; Zhang, JZ (通讯作者)，Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China.;Ye, L (通讯作者)，Binzhou Med Univ, Sch Publ Hlth & Management, Yantai, Peoples R China.

BIOORGANIC CHEMISTRY, 2023; 139 ():

Abstract

Polo-like kinase 1 (PLK1) is an attractive therapeutic target for the treatment of tumors, as it is an essential cellcycle regulator frequently overex......

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