Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes

Freyn, AW; Han, JLN; Guthmiller, JJ; Bailey, MJ; Neu, K; Turner, HL; Rosado, VC; Chromikova, V; Huang, M; Strohmeier, S; Liu, STH; Simon, V; Krammer, F; Ward, AB; Palese, P; Wilson, PC; Nachbagauer, R

Palese, P; Nachbagauer, R (corresponding author), Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA.; Palese, P (corresponding author), Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.; Nachbagauer, R (corresponding author), Moderna, Infect Dis Res, Cambridge, MA 02139 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021; 118 (8):

Abstract

In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/20......

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