Molecular and structural architecture of polyQ aggregates in yeast

Gruber, A; Hornburg, D; Antonin, M; Krahmer, N; Collado, J; Schaffer, M; Zubaite, G; Luchtenborg, C; Sachsenheimer, T; Brugger, B; Mann, M; Baumeister, W; Hartl, FU; Hipp, MS; Fernandez-Busnadiego, R

Baumeister, W; Fernandez-Busnadiego, R (reprint author), Max Planck Inst Biochem, Dept Struct Mol Biol, D-82152 Martinsried, Germany.; Hartl, FU; Hipp, MS (reprint author), Max Planck Inst Biochem, Dept Cellular Biochem, D-82152 Martinsried, Germany.; Har

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018; 115 (15): E3446

Abstract

Huntington's disease is caused by the expansion of a polyglutamine (polyQ) tract in the N-terminal exon of huntingtin (HttEx1), but the cellular mecha......

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