Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3, 4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors

Shao, XW; Pak, S; Velagapudi, UK; Gobbooru, S; Kommaraju, SS; Low, WK; Subramaniam, G; Pathak, SK; Talele, TT

Pathak, SK; Talele, TT (corresponding author), St Johns Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, 8000 Utopia Pkwy, Queens, NY 11439 USA.

BIOORGANIC CHEMISTRY, 2020; 102 ():

Abstract

Poly(ADP-ribose) polymerase 1 (PARP1), a widely explored anticancer drug target, plays an important role in single-strand DNA break repair processes. ......

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