Cryo-EM structure of a RAS/RAF recruitment complex

Park, E; Rawson, S; Schmoker, A; Kim, BW; Oh, S; Song, KK; Jeon, H; Eck, MJ

Jeon, H; Eck, MJ (通讯作者),Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Jeon, H; Eck, MJ (通讯作者),Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

RAF kinases are autoinhibited in the cytosol and are activated by recruitment to the plasma membrane by GTP-bound RAS. Here, the authors describe cryo......

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