Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti-CD74 autoantibodies in human ankylosing spondylitis

van Kempen, TS; Leijten, EFA; Lindenbergh, MFS; Nordkamp, MO; Driessen, C; Lebbink, RJ; Baerlecken, N; Witte, T; Radstake, TRDJ; Boes, M

Radstake, TRDJ (corresponding author), Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands.; Radstake, TRDJ; Boes, M (corresponding author), Univ Med Ctr Utrecht, Ctr Translat Immunol, Utrecht, Netherlands.; Boes, M (corresponding author), Univ Med Ctr Utrecht, Dept Pediat, Utrecht, Netherlands.

EUROPEAN JOURNAL OF IMMUNOLOGY, 2020; 50 (8): 1209

Abstract

Ankylosing spondylitis (AS) is associated with autoantibody production to class II MHC-associated invariant chain peptide, CD74/CLIP. In this study, w......

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