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Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (7)

CD4(+)CD8(+) double-positive thymocytes give rise to both conventional TCR alpha beta(+) T cells and invariant natural killer T cells (iNKT cells), bu......

Loss of microRNA-147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (8)

MicroRNA-147 (miR-147) had been previously found induced in synoviocytes by inflammatory stimuli derived from T cells in experimental arthritis. This ......

Innate lymphoid cells and cancer: Role in tumor progression and inhibition

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (9)

Innate lymphoid cells (ILCs), a critical component of the immune system, have recently been nominated as emerging players associated with tumor progre......

Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (9)

The increasing numbers of infected cases of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)......

Epigenetic regulation in antiviral innate immunity

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (7)

Emerging life-threatening viruses have posed great challenges to public health. It is now increasingly clear that epigenetics plays a role in shaping ......

Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (9)

Regulatory T (Treg) cells and T helper type 17 (Th17) cells play important roles in adaptive immune responses, antagonizing each other in immune disor......

Modulating oxidative stress counteracts specific antigen-induced regulatory T-cell apoptosis in mice

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (7)

Treg are known to have a central role in orchestrating immune responses, but less is known about the destiny of Treg after being activated by specific......

Altered follicular regulatory T (Tfr)- and helper T (Tfh)-cell subsets are associated with autoantibody levels in microscopic polyangiitis patients

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (7)

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is an autoimmune disease characterized by B cells-derived ANCAs, and ANCA was......

IL-33/ST2 as a potential target for tumor immunotherapy

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (8)

IL-33, a member of the IL-1 family, was initially reported to be expressed constitutively in the nucleus of tissue-lining and structural cells. Howeve......

UNC93B1 curbs cytosolic DNA signaling by promoting STING degradation

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (7)

UNC93B1 is a trafficking chaperone of endosomal Toll-like receptors (TLRs) and plays an essential role in the TLR-mediated innate signaling. However, ......

TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (7)

The type I interferon (IFN-I) system is important for antiviral and anticancer immunity. Prolonged activation of IFN/JAK/STAT signaling is closely ass......

Compromised long-lived memory CD8(+) T cells are associated with reduced IL-7 responsiveness in HIV-infected immunological nonresponders

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, 2021; 51 (8)

Immune deficiency is one of the hallmarks of HIV infection and a major cause of adverse outcomes in people living with HIV (PLWH). Long-lived memory C......

Musculin is highly enriched in Th17 and IL-22-producing ILC3s and restrains pro-inflammatory cytokines in murine colitis

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, ; ()

Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis......

Icaritin inhibits PD-L1 expression by Targeting Protein I kappa B Kinase alpha

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, ; ()

Icaritin, a small molecule currently being investigated in phase III clinical trials in China (NCT03236636 and NCT03236649) for treatment of advanced ......

Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock

期刊: EUROPEAN JOURNAL OF IMMUNOLOGY, ; ()

Pyroptosis is a type of acute cell death that mainly occurs in immune cells. It is characterized with robust release of inflammatory cytokines and has......

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