DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

Malavasi, ELV; Economides, KD; Grunewald, E; Makedonopoulou, P; Gautier, P; Mackie, S; Murphy, LC; Murdoch, H; Crummie, D; Ogawa, F; McCartney, DL; O'Sullivan, ST; Burr, K; Torrance, HS; Phillips, J; Bonneau, M; Anderson, SM; Perry, P; Pearson, M; Co

Millar, JK (reprint author), Univ Edinburgh, Ctr Genom & Expt Med, MRC Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.

TRANSLATIONAL PSYCHIATRY, 2018; 8 ():

Abstract

The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how thi......

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