PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Cao, YP; Zhang, XY; Wang, LN; Yang, QH; Ma, Q; Xu, JA; Wang, JJ; Kovacs, L; Ayon, RJ; Liu, ZP; Zhang, M; Zhou, YQ; Zeng, XQ; Xu, YM; Wang, Y; Fulton, DJ; Weintraub, NL; Lucas, R; Dong, Z; Yuan, JXJ; Sullivan, JC; Meadows, L; Barman, SA; Wu, CD; Quan,

Hong, M (reprint author), Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Drug Discovery Ctr, Shenzhen 518055, Peoples R China.; Hong, M (reprint author), Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen,

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019; 116 (27): 13394

Abstract

Increased glycolysis in the lung vasculature has been connected to the development of pulmonary hypertension (PH). We therefore investigated whether g......

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