Targeting MDM2 for the development of a new cancer therapy: progress and challenges

Aguilar, A; Thomas, JE; Wang, SM

Wang, SM (通讯作者)，Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.;Wang, SM (通讯作者)，Univ Michigan, Dept Program Chem Biol, Ann Arbor, MI 48109 USA.;Wang, SM (通讯作者)，Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA.;Wang, SM (通讯作者)，Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA.;Wang, SM (通讯作者)，Univ Michigan, Dept Rogel Canc Ctr, Ann Arbor, MI 48109 USA.

MEDICINAL CHEMISTRY RESEARCH, 2023; 32 (7): 1334

Abstract

For much of the past 20 years, MDM2 has been pursued as a cancer therapeutic target. Small molecule inhibitors that block the MDM2-p53 protein-protein......

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