Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling

Valentinis, B; Porcellini, S; Asperti, C; Cota, M; Zhou, D; Di Matteo, P; Garau, G; Zucchelli, C; Avanzi, NR; Rizzardi, GP; Degano, M; Musco, G; Traversari, C

Traversari, C (reprint author), MolMed SpA, I-20132 Milan, Italy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019; 20 (18):

Abstract

NGR-hTNF is a therapeutic agent for a solid tumor that specifically targets angiogenic tumor blood vessels, through the NGR motif. Its activity has be......

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