Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

Trayssac, M; Clarke, CJ; Stith, JL; Snider, JM; Newen, N; Gault, CR; Hannun, YA; Obeid, LM

Clarke, CJ; Hannun, YA (corresponding author), SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA.; Clarke, CJ; Hannun, YA (corresponding author), Stony Brook Canc Ctr, Stony Brook, NY 11794 USA.

CELL DEATH & DISEASE, 2021; 12 (1):

Abstract

Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Alth......

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