Bardoxolone conjugation enables targeted protein degradation of BRD4

Tong, BQ; Luo, M; Xie, Y; Spradlin, JN; Tallarico, JA; McKenna, JM; Schirle, M; Maimone, TJ; Nomura, DK

Maimone, TJ; Nomura, DK (corresponding author), Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA.; Maimone, TJ; Nomura, DK (corresponding author), Novartis Berkeley Ctr Prote & Chem Technol, Berkeley, CA 94720 USA.; Nomura, DK (corresponding author), Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA.; Nomura, DK (corresponding author), Univ Calif Berkeley, Dept Nutr Sci, Berkeley, CA 94720 USA.; Nomura, DK (corresponding author), Univ Calif Berkeley, Dept Toxicol, Berkeley, CA 94720 USA.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

Targeted protein degradation (TPD) has emerged as a powerful tool in drug discovery for the perturbation of protein levels using heterobifunctional sm......

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