CDK7 inhibition by THZ1 suppresses cancer stemness in both chemonaive and chemoresistant urothelial carcinoma via the hedgehog signaling pathway

Chow, PM; Chang, YW; Kuo, KL; Lin, WC; Liu, SH; Huang, KH

Huang, KH (corresponding author), Natl Taiwan Univ Hosp, Dept Urol, 7 Zhongshan S Rd, Taipei 100, Taiwan.; Liu, SH (corresponding author), Natl Taiwan Univ, Coll Med, Grad Inst Toxicol, 1,Sec 1,Jen Ai Rd, Taipei 100, Taiwan.; Huang, KH (corresponding author), Natl Taiwan Univ, Coll Med, 7 Zhongshan S Rd, Taipei 100, Taiwan.

CANCER LETTERS, 2021; 507 (): 70

Abstract

Urothelial carcinoma (UC) is the most common type of bladder cancer, with a 5-year survival rate of only 4.6% in metastatic UC. Despite the advances r......

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