HMG-CoA reductase degrader, SR-12813, counteracts statin-induced upregulation of HMG-CoA reductase and augments the anticancer effect of atorvastatin

Zhou, YX; Tashiro, J; Kamatani, S; Irie, N; Suzuki, A; Ishikawa, T; Warita, K; Oltvai, ZN; Warita, T

Warita, K (通讯作者)，Tottori Univ, Sch Vet Med, Dept Vet Anat, 4-101 Koyama Minami, Tottori 6808553, Japan.;Oltvai, ZN (通讯作者)，Univ Rochester, Dept Pathol & Lab Med, 601 Elmwood Ave, Rochester, NY 14642 USA.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023; 677 (): 13

Abstract

Statins are cholesterol-lowering drugs that have exhibited potential as cancer therapeutic agents. However, as some cancer cells are resistant to stat......

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