Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d

Zhang, B; Ye, YM; Ye, WW; Perculija, V; Jiang, H; Chen, YY; Li, Y; Chen, J; Lin, JY; Wang, SQ; Chen, Q; Han, YS; Ouyang, SY

Ouyang, SY (reprint author), Fujian Normal Univ, Key Lab Innate Immune Biol Fujian Prov, Biomed Res Ctr South China, Coll Life Sci,Minist Educ,Key Lab OptoElect Sci &, Fuzhou 350117, Fujian, Peoples R China.; Ouyang, SY (reprint author), Fujian Normal Uni

NATURE COMMUNICATIONS, 2019; 10 ():

Abstract

Cas13d, the type VI-D CRISPR-Cas effector, is an RNA-guided ribonuclease that has been repurposed to edit RNA in a programmable manner. Here we report......

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