Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain

Johe, P; Jung, S; Endres, E; Kersten, C; Zimmer, C; Ye, WX; Sonnichsen, C; Hellmich, UA; Sotriffer, C; Schirmeister, T; Neuweiler, H

Schirmeister, T (corresponding author), Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, D-55128 Mainz, Germany.; Neuweiler, H (corresponding author), Julius Maximilians Univ Wurzburg, Inst Biotechnol & Biophys, D-97074 Wurzburg, Germany.

ACS CHEMICAL BIOLOGY, 2021; 16 (4): 661

Abstract

Viral and parasitic pathogens rely critically on cysteine proteases for host invasion, replication, and infectivity. Their inhibition by synthetic inh......

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