In vitro and in vivo degradation of programmed cell death ligand 1 (PD-L1) by a proteolysis targeting chimera (PROTAC)

Wang, YB; Zhou, YY; Cao, S; Sun, Y; Dong, ZQ; Li, C; Wang, HR; Yao, YH; Yu, HY; Song, XY; Li, M; Wang, JF; Wei, MM; Yang, G; Yang, C

Wei, MM; Yang, G (corresponding author), Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.; Wang, JF (corresponding author), Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin 300060, Peoples R China.

BIOORGANIC CHEMISTRY, 2021; 111 ():

Abstract

Immunotherapy via immune checkpoints blockade has aroused the attention of researchers worldwide. Inhibition of the programmed cell death-1 (PD-1)/pro......

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