Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor

Honma, D; Kanno, O; Watanabe, J; Kinoshita, J; Hirasawa, M; Nosaka, E; Shiroishi, M; Takizawa, T; Yasumatsu, I; Horiuchi, T; Nakao, A; Suzuki, K; Yamasaki, T; Nakajima, K; Hayakawa, M; Yamazaki, T; Yadav, AS; Adachi, N

Adachi, N (reprint author), Daiichi Sankyo Co Ltd, Oncol Labs, Shinagawa Ku, 1-2-58 Hiromachi, Tokyo 1408710, Japan.

CANCER SCIENCE, 2017; 108 (10): 2069

Abstract

Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 and represses gene expression to regulate cell proliferation and differentiation.......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索