Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition

Cuffaro, D; Ciccone, L; Rossello, A; Nuti, E; Santamaria, S

Nuti, E (通讯作者)，Univ Pisa, Dept Pharm, I-56126 Pisa, Italy.;Santamaria, S (通讯作者)，Imperial Coll London, Dept Immunol & Inflammat, London W12 0NN, England.;Santamaria, S (通讯作者)，Univ Surrey, Fac Hlth & Med Sci, Sch Biosci & Med, Dept Biochem, Edward Jenner Bldg, Guildford GU2 7XH, Surrey, England.

JOURNAL OF MEDICINAL CHEMISTRY, 2022; 65 (20): 13505

Abstract

Osteoarthritis (OA) is the most common degenerative joint disease. In 1999, two members of the A Disintegrin and Metalloproteinase with Thrombospondin......

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