TCR-pMHC bond conformation controls TCR ligand discrimination

Sasmal, DK; Feng, W; Roy, S; Leung, P; He, YR; Cai, CF; Cao, GS; Lian, HD; Qin, J; Hui, EF; Schreiber, H; Adams, EJ; Huang, J

Huang, J (corresponding author), Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 USA.

CELLULAR & MOLECULAR IMMUNOLOGY, 2020; 17 (3): 203

Abstract

A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluoresce......

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