Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy

Chaves, AB; Peixoto, AS; Castro, E; Oliveira, TE; Perandini, LA; Moreira, RJ; Da Silva, RP; Da Silva, BP; Moretti, EH; Steiner, AA; Miyamoto, S; Yoshinaga, MY; Festuccia, WT

Chaves, AB; Festuccia, WT (通讯作者),Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Ave Prof Lineu Prestes 748, BR-05508900 Sao Paulo, Brazil.;Yoshinaga, MY (通讯作者),Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Ave Prof Lineu Prestes 748, BR-05508900 Sao Paulo, Brazil.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2023; 1868 (3):

Abstract

Total absence of adipose tissue (lipoatrophy) is associated with the development of severe metabolic disorders including hepatomegaly and fatty liver.......

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