An AKT/PRMT5/SREBP1 axis in lung adenocarcinoma regulates de novo lipogenesis and tumor growth

Liu, L; Yan, H; Ruan, MM; Yang, H; Wang, LH; Lei, B; Sun, XY; Chang, C; Huang, G; Xie, WH

Xie, WH (corresponding author), Shanghai Jiao Tong Univ, Dept Nucl Med, Shanghai Chest Hosp, Shanghai, Peoples R China.; Huang, G; Xie, WH (corresponding author), Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai, Peoples R China.

CANCER SCIENCE, 2021; 112 (8): 3083

Abstract

Protein kinase B (AKT) hyperactivation and de novo lipogenesis are both common in tumor progression. Sterol regulatory element-binding protein 1 (SREB......

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