Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD(+) biosynthesis pathway and NAMPT mutation

Guo, J; Lam, LT; Longenecker, KL; Bui, MH; Idler, KB; Glaser, KB; Wilsbacher, JL; Tse, C; Pappano, WN; Huang, TH

Huang, TH (reprint author), AbbVie Inc, Res & Dev Oncol Discovery, 1 North Waukegan Rd, N Chicago, IL 60064 USA.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017; 491 (3): 681

Abstract

Cancer cells have an unusually high requirement for the central and intermediary metabolite nicotinamide adenine dinucleotide (NAD(+)), and NAD(+) dep......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索