Discovery of PHGDH inhibitors by virtual screening and preliminary structure-activity relationship study

Zhang, FM; Yuan, L; Shi, XW; Feng, KR; Lan, XJ; Huang, C; Lin, GQ; Tian, P; Huang, M; Tang, S; Gao, DD

Tang, S (通讯作者)，Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.;Gao, DD (通讯作者)，Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China.

BIOORGANIC CHEMISTRY, 2022; 121 ():

Abstract

Phosphoglycerate dehydrogenase (PHGDH) is abnormally expressed in numerous malignant tumor cells and catalyzes the first step of serine biosynthesis, ......

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