Glycoengineering of pertuzumab and its impact on the pharmacokinetic/pharmacodynamic properties

Luo, C; Chen, S; Xu, N; Wang, C; Sai, WB; Zhao, W; Li, YC; Hu, XJ; Tian, H; Gao, XD; Yao, WB

Gao, XD; Yao, WB (reprint author), China Pharmaceut Univ, Sch Life Sci & Technol, Jiangsu Key Lab Druggabil Biopharmaceut, Nanjing 210009, Jiangsu, Peoples R China.

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

Pertuzumab is an antihuman HER2 antibody developed for HER2 positive breast cancer. Glycosylation profiles are always the important issue for antibody......

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