Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

Mahdy, HA; Ibrahim, MK; Metwaly, AM; Belal, A; Mehany, ABM; El-Gamal, KMA; El-Sharkawy, A; Elnhedawy, MA; Radwan, MM; Elsohly, MA; Eissa, IH

Eissa, IH (corresponding author), Al Azhar Univ, Fac Pharm Boys, Pharmaceut Med Chem & Drug Design Dept, Cairo 11884, Egypt.; El-Sharkawy, A (corresponding author), Al Azhar Univ, Fac Med, Dept Anat, Cairo, Egypt.; Elsohly, MA (corresponding author), Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA.

BIOORGANIC CHEMISTRY, 2020; 94 ():

Abstract

Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer. Accordingly, new quinazoline-based derivatives having the struct......

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