Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases

Kong, FD; Pang, XY; Zhao, JH; Deng, P; Zheng, MY; Zhong, DF; Chen, XY

Chen, XY (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China.

DRUG METABOLISM AND DISPOSITION, 2019; 47 (3): 238

Abstract

Nitrile group biotransformation is an unusual or minor metabolic pathway for most nitrile-containing drugs. However, for some cyanopyrrolidine dipepti......

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