Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine

Ma, LP; Wei, SJ; Yang, B; Ma, W; Wu, XL; Ji, HY; Sui, H; Chen, J

Chen, J (reprint author), Ningxia Med Univ, Sch Pharm, 1160 Shengli St, Yinchuan 750004, Ningxia, Peoples R China.

PHARMACEUTICAL BIOLOGY, 2017; 55 (1): 374

Abstract

Context: CYP3A4 and P-gp together form a highly efficient barrier for orally absorbed drugs and always share the same substrates. Our previous work re......

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