Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function

Capitano, ML; Mohamad, SF; Cooper, S; Guo, B; Huang, XX; Gunawan, AM; Sampson, C; Ropa, J; Srour, EF; Orschell, CM; Broxmeyer, HE

Capitano, ML; Broxmeyer, HE (corresponding author), Indiana Univ Sch Med, Dept Microbiol & Immunol, 950 West Walnut St,R2-302, Indianapolis, IN 46202 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (1):

Abstract

Bone marrow (BM) hematopoietic stem cells (HSCs) become dysfunctional during aging (i.e., they are increased in number but have an overall reduction i......

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