High-resolution structures of human Na(v)1.7 reveal gating modulation through alpha-pi helical transition of S6(IV)

Huang, GX; Liu, DL; Wang, WP; Wu, QR; Chen, JF; Pan, XJ; Shen, HZ; Yan, N

Shen, HZ (通讯作者)，Westlake Univ, Sch Life Sci, Key Lab Struct Biol Zhejiang Prov, Westlake Lab Life Sci & Biomed, 18 Shilongshan Rd, Hangzhou 310024, Zhejiang, Peoples R China.;Shen, HZ (通讯作者)，Westlake Inst Adv Study, Inst Biol, 18 Shilongshan Rd, Hangzhou 310024, Zhejiang, Peoples R China.;Yan, N (通讯作者)，Tsinghua Univ, Tsinghua Peking Joint Ctr Life Sci, Sch Life Sci, State Key Lab Membrane Biol,Beijing Adv Innovat C, Beijing 100084, Peoples R China.;Yan, N (通讯作者)，Princeton Univ, Dept Mol Biol, Pr

CELL REPORTS, 2022; 38 (4):

Abstract

Na(v)1.7 represents a preeminent target for next-generation analgesics for its critical role in pain sensation. Here we report a 2.2-angstrom resoluti......

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