Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

Kawamura, S; Matsushita, Y; Kurosaki, S; Tange, M; Fujiwara, N; Hayata, Y; Hayakawa, Y; Suzuki, N; Hata, M; Tsuboi, M; Kishikawa, T; Kinoshita, H; Nakatsuka, T; Sato, M; Kudo, Y; Hoshida, Y; Umemura, A; Eguchi, A; Ikenoue, T; Hirata, Y; Uesugi, M; Tateishi, R; Tateishi, K; Fujishiro, M; Koike, K; Nakagawa, H

Nakagawa, H (通讯作者)，Mie Univ, Dept Gastroenterol & Hepatol, 2-174 Edobashi, Tsu, Mie 5148507, Japan.

JOURNAL OF CLINICAL INVESTIGATION, 2022; 132 (11):

Abstract

Enhanced de novo lipogenesis mediated by sterol regulatory element-binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis......

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