BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association

Vido, MJ; Le, K; Hartsough, EJ; Aplin, AE

Aplin, AE (reprint author), Thomas Jefferson Univ, Dept Canc Biol, Philadelphia, PA 19107 USA.; Aplin, AE (reprint author), Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA.

CELL REPORTS, 2018; 25 (6): 1501

Abstract

Expression of aberrantly spliced BRAF V600E isoforms (BRAF V600E Delta Ex) mediates resistance in 13%-30% of melanoma patients progressing on RAF inhi......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索