A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity

Zdravkovic, A; Daley, JM; Dutta, A; Niwa, T; Murayama, Y; Kanamaru, S; Ito, K; Maki, T; Argunhan, B; Takahashi, M; Tsubouchi, H; Sung, P; Iwasaki, H

Tsubouchi, H; Iwasaki, H (corresponding author), Tokyo Inst Technol, Sch & Grad Sch Biosci & Biotechnol, Yokohama, Kanagawa 2268503, Japan.; Tsubouchi, H; Iwasaki, H (corresponding author), Tokyo Inst Technol, Inst Innovat Res, Yokohama, Kanagawa 2268503, Japan.; Sung, P (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem & Struct Biol, San Antonio, TX 78229 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021; 118 (11):

Abstract

The Mre11-Rad50-Nbs1 complex (MRN) is important for repairing DNA double-strand breaks (DSBs) by homologous recombination (HR). The endonuclease activ......

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