Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

Luo, PA; Zhang, Q; Zhong, TY; Chen, JY; Zhang, JZ; Tian, Y; Zheng, LH; Yang, F; Dai, LY; Zou, C; Li, ZJ; Liu, JH; Wang, JG

Wang, JG (通讯作者)，Chinese Acad Chinese Med Sci, Artemisinin Res Ctr, Beijing 100700, Peoples R China.;Wang, JG (通讯作者)，Chinese Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.;Wang, JG (通讯作者)，Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China.;Wang, JG (通讯作者)，Gannan Med Univ, Affiliated Hosp 1, Lab Med, Ganzhou 341000, Jiangxi, Peoples R China.;Li, ZJ; Wang, JG (通讯作者)，Jinan Univ, Clin Med Coll 2, Shenzhen P

MILITARY MEDICAL RESEARCH, 2022; 9 (1):

Abstract

Background Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies agains......

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