Unexpected CK2 beta-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2

Pietsch, M; Viht, K; Schnitzler, A; Ekambaram, R; Steinkruger, M; Enkvist, E; Nienberg, C; Nickelsen, A; Lauwers, M; Jose, J; Uri, A; Niefind, K

Uri, A (corresponding author), Univ Tartu, Inst Chem, 14A Ravila St, EE-50411 Tartu, Estonia.; Niefind, K (corresponding author), Univ Cologne, Inst Biochem, Dept Chem, Zulpicher Str 47, D-50674 Cologne, Germany.

BIOORGANIC CHEMISTRY, 2020; 96 ():

Abstract

Protein kinase CK2, a heterotetrameric holoenzyme composed of two catalytic chains (CK2 alpha) attached to a homodimer of regulatory subunits (CK2 bet......

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