Multicenter Phase II Trial of the WEE1 Inhibitor Adavosertib in Refractory Solid Tumors Harboring CCNE1 Amplification

Fu, SQ; Yao, SY; Yuan, Y; Previs, RA; Elias, AD; Carvajal, RD; George, TJ; Yuan, Y; Yu, LH; Westin, SN; Xing, Y; Dumbrava, EE; Karp, DD; Piha-Paul, SA; Tsimberidou, AM; Ahnert, JR; Takebe, N; Lu, KR; Keyomarsi, K; Meric-Bernstam, F

Fu, SQ (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Unit 0455,1515 Holcombe Blvd, Houston, TX 77030 USA.

JOURNAL OF CLINICAL ONCOLOGY, 2023; 41 (9): 1725

Abstract

PURPOSEPreclinical cancer models harboring CCNE1 amplification were more sensitive to adavosertib treatment, a WEE1 kinase inhibitor, than models with......

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