Development of a label-free FcRn-mediated transcytosis assay for in vitro characterization of FcRn interactions with therapeutic antibodies and Fc-fusion proteins

Chung, S; Lin, YWLD; Nguyen, V; Kamen, L; Zheng, K; Vora, B; Song, A

Chung, S (reprint author), Genentech Inc, Dept BioAnalyt Sci, 1 DNA Way, San Francisco, CA 94080 USA.

JOURNAL OF IMMUNOLOGICAL METHODS, 2018; 462 (): 101

Abstract

The neonatal Fc receptor (FcRn) binds to the Fc domain of IgG in a pH-dependent manner, guides the intracellular movement of the bound antibodies and ......

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