Differential effects of HIF2 alpha antagonist and HIF2 alpha silencing in renal cancer and sensitivity to repurposed drugs

Arnaiz, E; Miar, A; Bridges, E; Prasad, N; Hatch, SB; Ebner, D; Lawrie, CH; Harris, AL

Miar, A (corresponding author), Univ Oxford, Dept Oncol, Old Rd Campus Res Bldg, Oxford OX3 7DQ, England.

BMC CANCER, 2021; 21 (1):

Abstract

BackgroundIn clear cell renal cell carcinoma, 80% of cases have biallelic inactivation of the VHL gene, leading to constitutive activation of both HIF......

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